Principal Investigator: Frank A. Dinenno, Ph.D.

Lab Director

Education
Professional Positions
Honors and Awards
Publications
Teaching
Professional Service

Luckasen
Contact Information

Office: 215F Moby B Complex, Department of Health and Exercise Science, Colorado State University

Mailing Address: 220 Moby B Complex, Colorado State University, Fort Collins, CO 80524-1582

Phone: (970) 491-3203

Fax: (970) 491-0445

Email: frank.dinenno@colostate.edu


Biography:

After growing up in Southern California, I ditched my surfboard and attended the University of Arizona for my undergraduate degree. It was here in my final year of coursework that I was first exposed to research and decided to pursue graduate studies at the University of Colorado at Boulder under the direction of Dr. Douglas Seals. Our studies at that time were dedicated to understanding how aging and regular aerobic exercise training impacted large artery structure (i.e. wall thickness) and function (i.e. compliance), conduit and resistance vessel endothelial function, baroreflex control of the circulation, as well as peripheral blood flow under resting conditions. My interests in the control of blood flow and oxygen delivery led to me join the laboratory of Dr. Michael Joyner as a post-doctoral research fellow at the Mayo Clinic and Foundation in Rochester, Minnesota. It was in Dr. Joyner’s laboratory where I developed the expertise and training in utilizing pharmacological approaches to understand integrative vascular control mechanisms in conscious humans in vivo. Since arriving at Colorado State University in 2004, we continue to combine our expertise in pharmacology and physiology to allow us to test ideas related to peripheral blood flow and oxygen delivery control in healthy humans, and then build upon these basic physiology studies to further understand how aging and disease impact these control mechanisms. From a mentoring standpoint, I encourage my students and trainees to develop the critical thinking skills necessary to question current dogma and generate independent ideas, to take an integrative approach to their understanding of cardiovascular physiology and pathophysiology, and to dream up of ways in which we can test novel ideas that will move our research field forward. Personally, I am an avid soccer player and fly fisherman, and enjoy spending time with my wife and two children, as well as the great network of friends we have in the Fort Collins community.


Education:
  • 1996, B.S., Exercise Science, University of Arizona, Tucson, AZ.
  • 1998, M.S., Cardiovascular Physiology, Department of Kinesiology, University of Colorado at Boulder, Boulder, CO.
  • 2000, Ph.D., Cardiovascular Physiology, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO.

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Professional Positions:

Current

  • Associate Professor, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO.
  • Adjunct Faculty, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO.
  • Core Faculty Member, School of Biomedical Engineering, Colorado State University, Fort Collins, CO.

Previous

  • 2004 - 2009, Assistant Professor, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO.
  • 2000 - 2003, Postdoctoral Research Fellow, Anesthesia Research, Mayo Clinic and Foundation, Rochester, MN. 1998 - 2000, Research Assistant, Human Cardiovascular Research Laboratory, University of Colorado, Boulder, CO.

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Honors and Awards
  • 2009-2011, Monfort Professor, Colorado State University, Fort Collins, CO.
  • 2009, New Investigator Award, Cardiovascular Section of the American Physiological Society, Bethesda, MD.
  • 2007, New Investigator Award, Neural Control and Autonomic Regulation Section of the American Physiological Society, Bethesda, MD.
  • 2007, Mentor, Undergraduate Summer Research Fellowship Program, American Physiological Society (“The effect of sympathetic vasoconstriction on contraction-induced rapid vasodilation”)
  • 2007, Tenure-track faculty scholarly excellence award, College of Applied Human Sciences, Colorado State University, Fort Collins, CO.
  • 2002-2008, Clinical Loan Repayment Program Award, National Institutes of Health.
  • 2004, New Investigator Award, Environmental and Exercise Physiology Section of the American Physiological Society, Bethesda, MD.
  • 2002, Clinical Science Young Investigator Award, Cardiovascular Section of the American Physiological Society, Bethesda, MD.
  • 2002, Recognition Award for Meritorious Research by a Young Investigator, Neural Control and Autonomic Regulation Section of the American Physiological Society, Bethesda, MD. 2001, Michael J. Brody Young Investigator Award (finalist), American Physiological Society, Bethesda, MD.
  • 2001, Travel Award for the XXXIV International Congress of Physiological Sciences (Christchurch, New Zealand), American Physiological Society, Bethesda, MD.
  • 1999, Glenn/AFAR Scholarship for Research in the Biology of Aging: “Femoral Artery Intima-Media Thickness: Effects of Aging and Habitual Physical Activity”, American Federation for Aging Research.
  • 1999, Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award, American Physiological Society, Bethesda, MD.
  • 1998-2000, Travel Grant Award, University of Colorado, Boulder, CO.
  • 1998-1999, University of Colorado Graduate Fellowship, Boulder, CO.

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Publications

Visit PubMed to see most recent publication list: Frank A. Dinenno's Publications


Grant Support

Current Extramural Grant Support

  • 4/2010 - 3/2015 “Aging, Obstructive Sleep Apnea, and Impaired Peripheral Vascular Control During Systemic Hypoxia in Humans” ($1,787,140 over 5 years)

Current Intramural Grant Support

  • Colorado State University Monfort Professorship
  • 7/09 - present $130,000 for continued laboratory development

Completed Extramural Grant Support

  • NIH/NHLBI Exploratory/Developmental Grant Award (R21)
  • 4/2010 - 3/2013 “Role of circulating ATP and smooth muscle cell hyperpolarization in vascular control of healthy humans” ($404,250 over 3 years)

  • NIH/NHLBI Exploratory/Developmental Grant Award (R21)
  • 4/07 - 3/09 “Aging, Endothelial Dysfunction, and Impaired ATP-mediated Vasodilation in Humans” ($404,250 over 2 years)

  • NIH/NIA Mentored Research Scientist Award (KO1)
  • 9/03 - 9/08 “Aging and Sympathetic Vasoconstriction: rest vs exercise” ($565,000 over 5 years)

  • NIH/NIA Small Research Grant Award (RO3)
  • 9/06 - 9/08 “Aging, Endothelial Dysfunction, and Impaired Vascular Control During Exercise” ($120,164 over 2 years)

  • NIH/NIA National Research Service Award (NRSA)
  • ”Aging and alpha-adrenergic control of muscle blood flow” 9/00-8/03 ($123,000 over 3 years)

  • Glenn/AFAR Scholarship for Research in the Biology of Aging, American Federation for Aging Research
  • “Femoral Artery Intima-Media Thickness: Effects of Aging and Habitual Physical Activity” 1999-2000 ($5,500 total)

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Teaching
  • HES 444 – Physiology of Aging (undergraduate level)
  • HES 403 – Physiology of Exercise (undergraduate level)
  • HES 700 – Professional Skills for the Research Scientist (PhD level)
  • HES 735 – Human Cardiovascular Control (PhD level)

Professional Service

Professional Membership and Societies

  • 2006-present, Physiological Society
  • 1997-present, American Physiological Society
  • 2004-present, American Heart Association
  • 2001-2008, American College of Sports Medicine
  • 1999-2000, The Gerontological Society of America, Student Member and Campus Representative

Journal Referee

  • Journal of Physiology (editor; 2005 - 2012)
  • Journal of Applied Physiology (editorial board member July 2002-2009)
  • Circulation
  • Hypertension
  • American Journal of Physiology: Heart and Circulatory Physiology
  • American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology
  • American Journal of Physiology: Endocrinology and Metabolism
  • Medicine and Science in Sports and Exercise
  • Exercise and Sport Sciences Reviews
  • Journal of Clinical Endocrinology and Metabolism
  • Experimental Physiology
  • Gerontology
  • FASEB J

Grant Reviewing

  • 2009 - 2010 Ad hoc reviewer, NIH Clinical and Integrative Cardiovascular Sciences study section
  • 2011 – present, Regular member, NIH Clinical and Integrative Cardiovascular Sciences study section

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